Bo Nix Looks for a Spark as Denver Visits an Arizona Team Fresh Off an Upset
Denver is 4-2 on the strength of a defense that sacked Sam Darnold five times, while Bo Nix has thrown for 123 and 107 yards in the last two wins. Arizona comes home off an 18-16 upset of the Rams, without Jeremiyah Love, who was ruled out Friday, and with Trey McBride catching at least seven passes every week. The posted line is DEN -4.5 with a total of
43.5, and the contract below prices the win outright.
Kickoff
1:05 PM PT
4:05 PM ET, Sun, Oct 25
Stadium
State Farm Stadium
Glendale
On TV
CBS
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Denver Broncos are 4-2. Arizona Cardinals are 2-4. The posted line has Denver Broncos favoured by 4.5, with a total of 43.5. Kickoff is 4:05 PM ET on Sunday, October 25 at State Farm Stadium, Glendale.
The storyline. Denver is 4-2 on the strength of a defense that sacked Sam Darnold five times, while Bo Nix has thrown for 123 and 107 yards in the last two wins. Arizona comes home off an 18-16 upset of the Rams, without Jeremiyah Love, who was ruled out Friday, and with Trey McBride catching at least seven passes every week.
Broncos vs Cardinals at a glance
The Denver Broncos (4-2) visit the Arizona Cardinals (2-4) on Sunday, October 25, 2026, at 4:05 PM ET (1:05 PM PT) at State Farm Stadium on CBS. Denver is 4-2 on the strength of its defense, while Bo Nix has thrown for 123 and 107 yards the last two weeks. Arizona snapped a four-game losing streak with an 18-16 win at the Rams on Chad Ryland’s sixth field goal.
Kickoff and TV
Sunday, Oct. 25, 4:05 PM ET, 1:05 PM PT and Arizona time. CBS (ESPN).
Stadium and weather
State Farm Stadium, Glendale. The AccuWeather forecast on ESPN’s game page, read Saturday, lists 79 degrees at kickoff and no precipitation (AccuWeather).
Quarterbacks
Expected Bo Nix for Denver and Jacoby Brissett for Arizona. Arizona’s backup Carson Beck (back) is questionable after missing Friday’s practice (Cardinals.com).
The line
DraftKings had Denver a 4.5-point favorite with a total of 43.5 on ESPN’s game page Saturday morning, the same as Thursday (ESPN). On Kalshi the Broncos were 67¢ to sell and 68¢ to buy at 7:50 AM PT on Saturday, a cent firmer than Thursday.
Ruled out
Arizona: running back Jeremiyah Love (ankle), defensive lineman Walter Nolen III (ankle), lineman Jon Gaines II (knee and ankle) and safety Andrew Wingard (knee). Denver: running back Tyler Badie (thumb), safety Talanoa Hufanga and outside linebacker Jonah Elliss (ankles) (Cardinals.com).
Questionable
Arizona: safety Budda Baker (groin, illness), Beck, cornerback Max Melton (knee) and defensive lineman Darius Robinson (back). Denver: cornerback Pat Surtain II (ankle) and running back Jonah Coleman (ankle), who is working back from injured reserve. Receiver Jaylen Waddle (chest) practiced fully Friday and carries no status (Cardinals.com).
The matchup
Denver allows 208.5 passing yards a game, 10th fewest, and 139.8 rushing yards, 2nd most. Arizona allows 229.7 passing yards, 11th most, and 120.8 rushing yards, 13th most (ESPN team box scores, Weeks 1 to 6).
Six storylines for Broncos at Cardinals
Nix wants to carry more of the load
Bo Nix has 1,049 passing yards and six touchdowns on 60.3% passing, all on pace for career lows, and threw for 107 yards in the overtime win over Seattle. Sean Payton took some of it on himself: “I have to be better just relative to in the course of the game.” Nix: “I have to play better. We have to play better. The offense has to play better.” AP via ESPN
Denver keeps winning on defense
The Broncos hit Sam Darnold 17 times and sacked him five times, and Ja’Quan McMillian’s interception in overtime set up Wil Lutz’s 53-yard winner, on a night Denver had 168 yards of offense. “Defensively, we were magnificent,” Payton said, adding that 4-2 “could easily be 2-4.” AP via ESPN
Arizona finally finishes one
Chad Ryland kicked six field goals, the last from 43 yards as time expired, and Arizona beat the Rams 18-16 without a touchdown. It was Mike LaFleur’s first win over his former boss Sean McVay, and the Cardinals’ defense had given up 148 points in its previous four games. Arizona has lost nine straight at home. AP via ESPN · AP via ESPN
Love is out again
Jeremiyah Love (ankle) sat out the win at the Rams, did not practice Wednesday or Friday, and was ruled out on Friday’s report. LaFleur said Love is improving but the Cardinals will hold him until he is back to 100 percent. Bam Knight ran 15 times for 80 yards in his place, and Tyler Allgeier had 18 carries for 38. Denver allows 139.8 rushing yards a game, 2nd most. Rotowire · Cardinals.com · SI
McBride is the constant
Trey McBride has caught at least seven passes in all six games, 49 in all for 361 yards. Arizona traded Marvin Harrison Jr. to Houston after Week 5, which leaves Michael Wilson, Kendrick Bourne and Jalen Brooks outside. ESPN box scores · AP via ESPN
Zach Allen comes home
Allen has 4½ sacks through six games after last year’s All-Pro season. He played his first four years in Arizona and faces a reworked line with rookie Jayden Williams at left tackle, after Paris Johnson Jr. was lost for the season with a torn left biceps. Larry Fitzgerald goes into the Cardinals’ Ring of Honor at halftime. AP via ESPN
Broncos vs Cardinals injury report
Game statuses for both teams are from Friday’s final report (Cardinals.com, October 23), which carries both teams. Inactives come 90 minutes before kickoff, 11:35 AM PT, so anything here can still move.
Player
Team, pos
Status
What it changes
Jeremiyah Love
ARI, RB
Out
Ankle. Bam Knight and Tyler Allgeier split the work in Week 6.
Walter Nolen III
ARI, DL
Out
Ankle.
Jon Gaines II
ARI, OL
Out
Knee and ankle. Hayden Conner starts at right guard.
Andrew Wingard
ARI, S
Out
Knee.
Budda Baker
ARI, S
Questionable
Groin and illness. Limited Friday.
Carson Beck
ARI, QB
Questionable
Back. Brissett’s backup; did not practice Friday.
Max Melton
ARI, CB
Questionable
Knee.
Darius Robinson
ARI, DL
Questionable
Back. Limited Friday.
Garrett Williams
ARI, CB
No status
Knee. Full Friday.
Jedrick Wills Jr.
ARI, OL
No status
Illness. Full Friday.
Tyler Badie
DEN, RB
Out
Thumb.
Talanoa Hufanga
DEN, S
Out
Ankle.
Jonah Elliss
DEN, OLB
Out
Ankle.
Pat Surtain II
DEN, CB
Questionable
Ankle. Limited Friday.
Jonah Coleman
DEN, RB
Questionable
Ankle. Full Friday, working back from injured reserve.
Week 6: 15 carries for 80 yards, 2 catches for 18.
Led Arizona’s backfield at the Rams with Love out.
Why each side can win
The Broncos
Denver’s defense allows 208.5 passing yards a game, 10th fewest, and just beat Seattle with five sacks. Dobbins has been steady, and Arizona allows 120.8 rushing yards a game.
The Cardinals
Arizona is home off its best defensive game, McBride is the most reliable target on the field, and Denver allows 139.8 rushing yards a game, 2nd most. Nix has thrown for 230 yards in the last two games combined.
Records, venue, spread and total from the ESPN scoreboard, read 2026-10-20.1
Implied points is half the total moved half the spread, which is arithmetic on the two numbers above, not a projection.
What the market says
The posted line has Denver Broncos favoured by 4.5 on the road, with a total of 43.5. A spread is the market's estimate of the margin, not a result; the Kalshi contract below prices the win outright.
The two venue prices sit at the top of this page and are read live when it loads. A
contract settles at $1.00 if that team wins and $0 if it loses, so a price in cents is
that market’s implied chance of the win. Prices are the venues’, not our picks,
and the two rarely agree to the cent.
A spread and a contract price are two different questions. The spread is the market’s
estimate of the margin; the contract prices the win outright, and it is the one you can sell
before the game ends. Books differ on the spread itself: our read found two games where a
second book had a different number the same afternoon.1
Broncos vs Cardinals player props on Kalshi
Every player contract Kalshi has listed for this game, live: passing, rushing and
receiving yards, receptions, carries and touchdowns. Each chip is a threshold and the
price to buy YES on it.
Reading the Kalshi board.
Trading it: the case each way
No plan is posted on this game. The props section above is about one player; this is
about the game itself.
The question on Arizona Cardinals
Arizona Cardinals are 2-4 and they are at home, and the line makes them the underdog by 4.5. Decide what chance you
would give them, in cents, before you read the board. If your number is above the ask,
that is the trade; if it is not, there is no trade here.
The question on Denver Broncos
Denver Broncos are 4-2 and favoured by 4.5. A favourite contract costs most of a dollar, so the
money at risk is large against the money to be made. Work out what you lose if it goes
wrong before you decide what you make if it goes right.
Whatever you decide, write the entry, the sell target and the hold rule
before kickoff, and remember the fee is largest near 50¢.
How the fee works
Questions people ask about this game
Who is favored in Broncos vs Cardinals on October 25, 2026?
The Denver Broncos are 4.5-point favorites over the Arizona Cardinals at DraftKings, with a total of 43.5, as shown on ESPN’s game page Saturday, October 24, 2026. Kalshi had Denver at 67 to 68 cents to win at 7:50 AM PT on Saturday.
What time is Broncos vs Cardinals and what channel is it on?
The Broncos play the Cardinals on Sunday, October 25, 2026, at 4:05 PM ET (1:05 PM PT) at State Farm Stadium in Glendale. The game is on CBS.
Is Jeremiyah Love playing against the Broncos?
No. Arizona ruled him out on Friday’s final injury report with an ankle injury, his second straight missed game (Cardinals.com, October 23). Bam Knight ran for 80 yards in his place at the Rams.
Is Jaylen Waddle playing for the Broncos?
He carries no game status on Friday’s final report. Waddle was limited Wednesday with a chest injury and practiced fully on Friday (Cardinals.com, October 23).
What is the weather for Broncos vs Cardinals?
The AccuWeather forecast on ESPN’s game page, read Saturday, lists 79 degrees at kickoff in Glendale with no precipitation.
What is Agent Brad’s parlay for Broncos vs Cardinals?
Agent Brad is sitting this one out, and he will be right back with you for the next game. Trey McBride has caught at least seven passes in every game and the market already prices that in, while Bo Nix has thrown for 123 and 107 yards the last two weeks, which keeps Denver’s passing lines hard to lean on.
How many points is each team priced for in Denver Broncos at Arizona Cardinals?
Half the total moved half the spread puts Denver Broncos at about 24 points and Arizona Cardinals at about 19.5. That is arithmetic on the two posted numbers, not a score projection, and it is the figure most fantasy decisions on this game turn on.
How often does each leg of a pick'em entry need to hit to break even?
A pick'em entry is a parlay, so every leg has to land: two legs you price at 60 per cent are 36 per cent together, and three are 22 per cent. If your board pays N times the entry on an L-leg play, the entry needs to win one divided by N of the time, so each leg needs the L-th root of that. A two-leg play paying 3x needs each leg at about 57.7 per cent, and a four-leg play paying 10x needs each at about 56.2 per cent. Multipliers differ by state, board and promotion, so use your own terms.
Sources
Every stored figure on this page came from one of these, read 2026-10-20. Lines move
and injury news lands after that; the prices in the strip and on the board are read live when
the page loads, not written into it.
ESPN NFL scoreboard: schedule, records, venue, broadcast, the posted spread and the total. site.api.espn.com
ESPN NFL game summaries for the completed Week 1 to Week 6 games: the six-game player totals, summed from the box scores. espn.com
Kalshi public markets API, the Denver Broncos at Arizona Cardinals game market: the contract this page links to. Prices are read live in your browser, never stored here. external-api.kalshi.com
The headline on this page: Bo Nix has 1,049 passing yards and six touchdowns on 60.3% passing, all on pace for career lows, and threw for 107 yards in the overtime win over Seattle. Read 2026-10-20. www.espn.com
PM Countdown is not affiliated with or endorsed by Kalshi, Polymarket, ESPN or
the NFL. Prices shown are the venues’, not our picks.
21+Only risk what you can afford to lose. Set a money limit before you start, take profits on purpose and stop when you hit your limit. Not financial or betting advice. Gambling problem? Call or text 1-800-MY-RESET.